| Abstract: | BackgroundMetabolic syndrome (MetS) is a complex disorder characterized by coexistence
of several cardiometabolic (CM) factors, i.e. hyperlipidemia, obesity, high
blood pressure and insulin resistance. The presence of MetS is strongly
associated with increased risk of cardiovascular disease (CVD). The syndrome
was originally defined as an adult disorder, but MetS has become
increasingly recognized in children and adolescents.MethodsGenetic variants influence biological components common to the CM factors
that comprise MetS. We investigated single locus associations between six
single nucleotide polymorphisms (SNPs), previously shown to modulate lipid
or sex hormone binding globulin (SHBG) levels, with MetS in a Turkish
pediatric cohort (37 cases, 323 controls).ResultsLogistic regression analysis revealed a significant association between
rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006). The
association with MetS remained after sequential adjustment for each CM
factor included in the syndrome definition, indicating that the identified
association is not being driven by any single trait. A relationship between
rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS
status. In control subjects, the A allele of rs1799941 associated with a
significant increase in SHBG levels (p = 0.012), while in cases there was no
association between rs1799941 and SHBG levels (p = 0.963).ConclusionsThe significant association between rs1799941 and MetS in children is not
contingent on any single CM trait. Additionally, the presence of MetS may
abrogate effect of rs1799941 polymorphism on SHBG levels in children. |
