Prevalence of plasmid-mediated quinolone resistance determinants among oxyiminocephalosporin-resistant Enterobacteriaceae in Argentina |
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| Authors: | Giovanna Rincon Cruz Marcela Radice Samantha Sennati Lucia Pallecchi Gian María Rossolini Gabriel Gutkind Jose Alejandro Di Conza |
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| Institution: | 1. Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina;2. Dipartimento di Biotecnologie, Sezione di Microbiologia, Università di Siena, Siena, Italy;3. Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina;4. Escuela de Bacteriología, Universidad Industrial de Santander, Bucaramanga, Colombia |
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| Abstract: | High quinolone resistance rates were observed among oxyiminocephalosporin-resistant enterobacteria. In the present study, we searched for the prevalence of plasmid-mediated quinolone resistance (PMQR) genes within the 55 oxyiminocephalosporin-resistant enterobacteria collected in a previous survey. The main PMQR determinants were aac(6'')-Ib-cr and qnrB, which had prevalence rates of 42.4% and 33.3%, respectively. The aac(6'')-Ib-cr gene was more frequently found in CTX-M-15-producing isolates, while qnrB was homogeneously distributed among all CTX-M producers. |
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| Keywords: | PMQR ESBL-producing Enterobacteriaceae fluoroquinolone |
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