A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment |
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| Authors: | John Carl Panetta |
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| Affiliation: | (1) Department of Mathematics and Statistics, Old Dominion University, 23529 Norfolk, VA, USA;(2) Present address: Department of Mathematics, Penn State Erie, The Behrend College, Station Road, 16563-0203 Erie, PA |
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| Abstract: | A competition model describing tumor-normal cell interaction with the added effects of periodically pulsed chemotherapy is discussed. The model describes parameter conditions needed to prevent relapse following attempts to remove the tumor or tumor metastasis. The effects of resistant tumor subpopulations are also investigated and recurrence prevention strategies are explored. |
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