Glucagon and glicentin immunoreactive cells in human colon |
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Authors: | P C Colony V Helmstaedter A J Moody J C Garaud Prof W G Forssmann |
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Institution: | (1) Department of Anatomy III, University of Heidelberg, Federal Republic of Germany;(2) Department of Anatomy, Harvard Medical School, Boston, USA;(3) Novo Research Institute Bagsvaerd, Denmark;(4) Unité 61 INSERM, Strasbourg, France;(5) Department of Medicine, Peter Bent Brigham Hospital, Boston, USA;(6) Anatomisches Institut III der Universität, Im Neuenheimer Feld 307, D-6900 Heidelberg 1, Federal Republic of Germany |
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Abstract: | Summary An immunohistochemical study of glucagon and glicentin immunoreactive endocrine cells in the human colon epithelium was performed. Serial sections and qualitative analysis show a cell population containing both immunoreactivities. However, there is another cell population exhibiting only an immunoreactivity with glicentin. The exact distribution of these immunoreactive endocrine cells within the colon crypt segments is also analysed. The significance of these findings concerning the synthesis of glucagon and glicentin and their function is discussed.Supported by a grant of the German Research Foundation and by a research grant AM 17537 from the National Institutes of Health, Bethesda, Maryland (USA) Dr. Colony was the recipient of a stipend for a research project in the Federal Republic of Germany from the Deutscher Akademischer Austauschdienst (DAAD) |
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Keywords: | Glucagon Glicentin Human Colon Immunohistochemistry |
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