Estradiol receptors in human liver |
| |
| Authors: | M J Duffy G J Duffy |
| |
| Affiliation: | 1. Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA;2. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;1. Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha, Hunan 410128, China;2. College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China;3. Department of Bioengneering and Environmental Science, Changsha University, Changsha, Hunan 410000, China;1. Children''s Hospital Colorado, Aurora, Colorado, USA;2. University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA |
| |
| Abstract: | High affinity, low capacity estradiol binding activity was detected in cytoplasmic fractions from human liver. The binding activity was clearly differentiated from that due to contaminating serum proteins. Binding was specific for estrogens and there was no evidence of specifically bound androgen or progestin. Heating the cytoplasmic fraction or treatment with proteolytic enzymes destroyed activity, suggesting that the binding component was a protein. It is concluded that human liver contains a specific estradiol receptor with steroid specificity similar to that found in other estrogen target tissues. The presence of the estradiol receptor may be responsible for action of estradiol in modulating the synthesis of specific proteins in liver. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
