Vanadate stimulates ornithine decarboxylase activity in C3H/10T1/2 cells. |
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| Authors: | A J Davison A Stern D J Fatur S S Tsang |
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| Affiliation: | Bioenergetics Research Laboratory, School of Kinesiology, Faculty of Applied Sciences Simon Fraser University, Burnaby B.C., Canada. |
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| Abstract: | Ornithine decarboxylase (ODC) activity of C3H/10T1/2 cells reflects their response to conflicting actions of many tumor promoters and tumor suppressors. In cultured C3H/10T1/2 cells, addition of vanadate (50 nM) increased ODC activity. Over the range 0.05-5 microM, vanadate increased ODC levels in a dose dependent manner to 11 times control levels. The presence of retinoic acid (5 microM) or the absence of fetal calf serum blocked the stimulation by vanadate. |
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