Aphagia in the rat following microinjection of neurotensin into the ventral tegmental area |
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| Authors: | M F Hawkins |
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| Affiliation: | 1. Department of Anesthesiology, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai, China;2. Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People''s Hospital affiliated to Tongji University School of Medicine, Shanghai, China;3. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States |
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| Abstract: | Neurotensin was microinjected into the lateral cerebral ventricle and the ventral tegmental area of rats which had been deprived of food for 18 hours. Both routes of administration resulted in a significant reduction of food intake compared to vehicle control injections. Additionally, the dose of neurotensin required to produce aphagia following ventral tegmental injection was substantially less than the dose required by the ventricular route. The results are discussed in relation to a possible site and mode of action for this neuropeptide. |
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