Comparison of in vivo and in vitro SCE induction |
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| Authors: | Edward L. Schneider Janet Lewis |
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| Affiliation: | Section on Cellular and Genetics, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224 U.S.A. |
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| Abstract: | In vivo and in vitrod sister-chromatid exchange (SCE) induction and cell replication kinetics were compared in P388 cells exposed to 4 mutagens. While concordance was observed between SCE induction and inhibition of cell replication kinetics, certain mutagens were more potent in vivo while others were more potent in vitro. These results indicate that caution should be applied before equating in vivo and in vitro mutagen exposures. |
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