The induction of chromosomal structural changes in male chickens by the alkylating agents: triethylene melamine and ethyl methanesulfonate |
| |
| Authors: | Nancy Wang Robert N. Shoffner Jack S. Otis Kimberly M. Cheng |
| |
| Affiliation: | Department of Genetics and Cell Biology and Animal Sciences, University of Minnesota, St. Paul, MN 55108, U.S.A. |
| |
| Abstract: | E. coli chromosomal DNA wastreated with various Pt co-ordiantion compounds and then used as donor DNA in E. coli transformation. Genetic analysis of transformants obtained with Pt-treated DNA showed effects of cis-diamminedichloroplatinum(II) (cis-Pt(II)) and cis-dimethyl-1,3-diaminopropane CL4 (cis-Pt(IV) (DMDAP) on the processing of DNA. With trans-diamminedichloroplatinum(II) (trans-Pt(II)) appllied in similar concentrations no effects were found.The effects of cis-Pt(II) and cis-Pt(IV) (DMDAP) on the genetic processing were different. The effects of cis-Pt(II) could be explained by assuming intra-strand crosslinks as an important lesion. |
| |
| Keywords: | EMS ethyl methanesulfonate TEM triethylenemelamine |
| 本文献已被 ScienceDirect 等数据库收录！ |
