Effect of hormone treatment on spontaneous and radiation-induced chromosomal breakage in normal and dwarf mice |
| |
| Authors: | Paul P.W. van Buul Sylvia van Buul-Offers |
| |
| Affiliation: | 1. Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL Leiden The Netherlands;2. Department of Pediatrics, University of Utrecht, Wilhelmina Children''s Hospital, Nieuwe Gracht 137, 3512 LK Utrecht, The Netherlands;3. J.A. Cohen Institute, Interuniversity Institute for Radiopathology and Radiation Protection, 2333 AD Leiden The Netherlands |
| |
| Abstract: | Treatment of dwarf mice with growth hormone, insulin and testosterone had no effect on the spontaneous frequencies of micronuclei (MN) in bone-marrow cells, whereas thyroxine decreased these frequencies. The induction of MN by X-rays and mitomycin C was significantly lower in dwarf mice than in normal mice. Treatment with thyroxine plus growth hormone restored normal radiosensitivity in dwarfs. |
| |
| Keywords: | BCNU 1,3-bis(2-chloroethyl)nitrosourea BHCNU 1,3-bis(trans-4-hydroxycyclohexyl)-1-nitrosourea CCNU 1-(2-chloroethyl)-1-nitroso-3-cyclohexylurea CHLZ chlorozotocin ENU MNU |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
