Mathematical Model of Growth Factor Driven Haptotaxis and Proliferation in a Tissue Engineering Scaffold |
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Authors: | J V Pohlmeyer S L Waters L J Cummings |
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Institution: | 1. Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ, 07102, USA 2. Oxford Centre for Industrial and Applied Mathematics, Oxford Centre for Collaborative Applied Mathematics, University of Oxford, 24–29 St Giles’, Oxford, OX1 3LB, UK
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Abstract: | Motivated by experimental work (Miller et al. in Biomaterials 27(10):2213–2221, 2006, 32(11):2775–2785, 2011) we investigate the effect of growth factor driven haptotaxis and proliferation in a perfusion tissue engineering bioreactor, in which nutrient-rich culture medium is perfused through a 2D porous scaffold impregnated with growth factor and seeded with cells. We model these processes on the timescale of cell proliferation, which typically is of the order of days. While a quantitative representation of these phenomena requires more experimental data than is yet available, qualitative agreement with preliminary experimental studies (Miller et al. in Biomaterials 27(10):2213–2221, 2006) is obtained, and appears promising. The ultimate goal of such modeling is to ascertain initial conditions (growth factor distribution, initial cell seeding, etc.) that will lead to a final desired outcome. |
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