Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast |
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| Authors: | Cheeseman Iain M Drubin David G Barnes Georjana |
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| Affiliation: | Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA. |
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| Abstract: | Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation. |
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