| Microinjection of oxytocin into limbic-mesolimbic brain structures disrupts heroin self-administration behavior: a receptor-mediated event? |
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Microinjection of oxytocin into limbic-mesolimbic brain structures disrupts heroin self-administration behavior: A receptor-mediated event? |
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| Authors: | R Ibragimov G L Kovács G Szabó G Telegdy |
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| Institution: | 1. Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah, Salt Lake City, Utah;2. Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah;3. Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York;1. State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, China;2. College of Architecture and Civil Engineering, Zhongyuan University of Technology, Zhengzhou 450007, China;1. Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;2. Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China;3. Rehabilitation College of Capital Medical University, China Rehabilitation Research Center, Beijing 100068, China;4. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China;5. Department of Psychology, Queens College, The City University of New York, Queens, New York 11367, USA |
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| Abstract: | The systemic injection of oxytocin (OXT) decreases the self-administration of heroin in heroin-tolerant rats. Since OXT-ergic binding sites are present in limbic and mesolimbic brain regions, the effects of intracerebral microinjections of OXT were investigated. In heroin-tolerant rats, the microinjection of OXT (2 ng) into the anterodorsal part of the nucleus accumbens or into the ventral hippocampus disrupted the self-administration of heroin. The effect of intrahippocampal microinjections lasted longer than that of intraaccumbens injections. The administration of N alpha-acetyl-(2-0-methyltyrosine)-oxytocin (ACME-OXT), an inhibitor of oxytocin receptors, prevented the disruptive effect of intrahippocampal OXT injections on heroin self-administration. It is concluded that limbic-mesolimbic brain structures have an essential role in the expression of the disruptive action of OXT on heroin self-administration. It appears that OXT-ergic binding sites mediate the effects of OXT. |
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