RNA cleavage by 2,9-diamino-1,10-phenanthroline PNA conjugates |
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Authors: | Murtola Merita Ossipov Dimitri Sandbrink Jessica Strömberg Roger |
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Institution: | Department of Biosciences and Nutrition, Karolinska Institutet, NOVUM, S-14157 Huddinge, Sweden. |
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Abstract: | We report on the synthesis of 2,9-diamino-1,10-phenanthroline PNA conjugates as well as on their action in cleavage of a target RNA. Synthesis of the PNA conjugates are performed on solid support and the phenanthroline derivative is conjugated either to the amino-end or to a centrally positioned diaminopropionic acid in the PNA via a urea linker. Cleavage of the target RNA is achieved and compared to cleavage with the corresponding 2,9-dimethyl-1,10-phenanthroline and glycine conjugates. |
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