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Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib |
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| Authors: | Navratna Vajpai André Strauss Gabriele Fendrich Sandra W Cowan-Jacob Paul W Manley Wolfgang Jahnke Stephan Grzesiek |
| Institution: | (1) Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland;(2) Novartis Institutes for Biomedical Research, Basel, Switzerland |
| Abstract: | Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
| Keywords: | Tyrosine kinases Glivec BCR-ABL Chronic myelogenous leukemia Selective labeling |
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