(1) Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland;(2) Novartis Institutes for Biomedical Research, Basel, Switzerland
Abstract:
Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase,
which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase
domain in complex with imatinib.
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