Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis |
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| Authors: | Joseph Horzempa,Paul E Carlson Suffix" >Jr,Dawn M O'Dee,Robert MQ Shanks,Gerard J Nau |
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| Affiliation: | (1) Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA;(2) Charles T. Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, PA 15213, USA;(3) Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA;(4) Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA |
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| Abstract: | Background After infecting a mammalian host, the facultative intracellular bacterium,Francisella tularensis, encounters an elevated environmental temperature. We hypothesized that this temperature change may regulate genes essential for infection. |
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