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Biaryl amide glucagon receptor antagonists |
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| Authors: | Kurukulasuriya Ravi Sorensen Bryan K Link James T Patel Jyoti R Jae Hwan-Soo Winn Marty X Rohde Jeffrey R Grihalde Nelson D Lin Chun W Ogiela Christopher A Adler Andrew L Collins Christine A |
| Institution: | Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. ravi.kurukulasuriya@abbott.com |
| Abstract: | Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge. |
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