Binding of lac repressor to the secondary lac operator in Escherichia coli. |
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Authors: | Alain Rambach and Mai Lebastard |
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Institution: | (1) Groupe INSERM-U.163, Institut Pasteur, 28, Rue du Dr Roux, 15e Paris, France |
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Abstract: | Summary In the lac operon, the existence of a secondary repressor binding site, inside Z gene, had been inferred from in vitro binding studies (Reznikoff et al., 1974; Gilbert et al., 1975).A serie of deletions have been constructed from a lac transducing bacteriophage. Some of those deleted bacteriophages have still the property of derepressing a chromosomal lac operon, even though they do not contain any more the lac operator. This phenomenon is an indication that the secondary repressor binding site is also active in vivo. |
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