Hormone changes occurring during second trimester abortion induced with 15(S)-15-methyl prostaglandin F2α |
| |
| Authors: | Stephen L. Corson Ronald J. Bolognese Terry J. Gilbertson Joseph T. Sobota |
| |
| Affiliation: | 1. Department of Obstetrics and Gynecology Pennsylvania Hospital University of Pennsylvania, School of Medicine Philadelphia, Pennsylvania 19107 USA;2. Clinical Research Laboratories The Upjohn Company Kalamazoo, Michigan 49001 USA |
| |
| Abstract: | Changes in progesterone, human placental lactogen (HPL), cortisol and estradiol-17β were measured during second trimester abortion induced by I.M. 15-methyl PGF2α. A rapid decline in progesterone and HPL was found, indicating perhaps an initial effect on the placenta. A rapid rise in cortisol was found, but it is not clear if this is due to stress or part of the termination mechanism. The changes of estradiol were not as distinct and may reflect opposite effects of the prostaglandin on the placenta and adrenals. Similar hormonal changes were observed regardless of the duration of gestation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
