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Proteolytic modification of human phosphoglycerate kinase from lymphoblasts |
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| Authors: | T.O. Tollefsbol R.W. Gracy |
| Affiliation: | Departments of Chemistry and Biochemistry, North Texas State University and Texas College of Osteopathic Medicine, Denton, Texas 76203 U.S.A. |
| Abstract: | During phytohemagglutinin and concanavalin A-induced transformation of human lymphocytes, phosphoglycerate kinase (PGK) exhibits new electrophoretic forms (pI = 8.5–8.9). Electrophoresis and electrofocusing showed that the new forms are not due to expression of the autosomally linked isozyme found in sperm (PGK-B; pI = 9.7). The multiple electrophoretic forms are the result of protease modification of the sex-linked PGK-A isozyme. |
| Keywords: | To whom requests for reprints and correspondence should be addressed: Department of Biochemistry North Texas State University Denton Tex. 76203. |
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