The capsule polysaccharide structure and biogenesis for non-O1 Vibrio cholerae NRT36S: genes are embedded in the LPS region |
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| Authors: | Yuansha Chen Peter Bystricky Jacob Adeyeye Pinaki Panigrahi Afsar Ali Judith A Johnson CA Bush Jr" target="_blank">JG MorrisJr OC Stine |
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| Affiliation: | (1) Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, 21201 Baltimore, MD, USA;(2) Department of Chemistry and Biochemistry, University of Maryland, 21250 Baltimore County Baltimore, MD, USA;(3) Department of Pediatrics, University of Maryland, Baltimore, 21201 Baltimore, MD, USA;(4) Department of Pathology, University of Maryland, Baltimore, 21201 Baltimore, MD, USA;(5) Clinical Microbiology, Veterans Affairs Maryland Health Care System, 21201 Baltimore, MD, USA;(6) Slovak Medical University, SK-83303 Bratislava, Slovakia;(7) Department of Natural Sciences, Coppin State College, Baltimore, MD 21216, USA |
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| Abstract: | Background In V. cholerae, the biogenesis of capsule polysaccharide is poorly understood. The elucidation of capsule structure and biogenesis is critical
to understanding the evolution of surface polysaccharide and the internal relationship between the capsule and LPS in this
species. V. cholerae serogroup O31 NRT36S, a human pathogen that produces a heat-stable enterotoxin (NAG-ST), is encapsulated. Here, we report
the covalent structure and studies of the biogenesis of the capsule in V. cholerae NRT36S. |
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