Bluetongue virus RNA binding protein NS2 is a modulator of viral replication and assembly |
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| Authors: | Alak Kanti Kar Bishnupriya Bhattacharya Polly Roy |
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| Institution: | (1) Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK;(2) Dana-Farber Cancer Institute, 44 Binney Street, Jimmy Fund 608, Boston, Massachusetts 02115, USA |
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| Abstract: | Background Bluetongue virus (BTV) particles consist of seven structural proteins that are organized into two capsids. In addition, BTV
also encodes three non-structural (NS) proteins of which protein 2 (NS2) is the RNA binding protein and is also the major
component of virus encoded inclusion bodies (VIBs), which are believed to be virus assembly sites. To investigate the contribution
of NS2 in virus replication and assembly we have constructed inducible mammalian cell lines expressing full-length NS2. In
addition, truncated NS2 fragments were also generated in an attempt to create dominant negative mutants for NS2 function. |
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