MED: a new non-supervised gene prediction algorithm for bacterial and archaeal genomes |
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| Authors: | Huaiqiu Zhu Gang-Qing Hu Yi-Fan Yang Jin Wang Zhen-Su She |
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| Institution: | (1) State Key Lab for Turbulence and Complex Systems and Department of Biomedical Engineering, Peking University, Beijing, 100871, China;(2) Center for Theoretical Biology and Department of Physics, PekingUniversity, Beijing, 100871, China;(3) State Key Lab of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China;(4) Department of Mathematics, UCLA, , Los Angeles, CA 90095, USA |
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| Abstract: | Background Despite a remarkable success in the computational prediction of genes in Bacteria and Archaea, a lack of comprehensive understanding
of prokaryotic gene structures prevents from further elucidation of differences among genomes. It continues to be interesting
to develop new ab initio algorithms which not only accurately predict genes, but also facilitate comparative studies of prokaryotic genomes. |
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