A mechanism for the sharp transition of morphogen gradient interpretation in <Emphasis Type="Italic">Xenopus</Emphasis> |
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| Authors: | Yasushi Saka James C Smith |
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| Institution: | (1) Department of Zoology, Wellcome Trust/Cancer Research UK Gurdon Institute and University of Cambridge, Tennis Court Road, CB2 1QN Cambridge, UK;(2) Interdisciplinary Research Institute, Institut de Biologie de Lille, 1 rue du Professeur Calmette, BP447, 59021 Lille Cedex, France |
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| Abstract: | Background One way in which positional information is established during embryonic development is through the graded distribution of
diffusible morphogens. Unfortunately, little is known about how cells interpret different concentrations of morphogen to activate
different genes or how thresholds are generated in a morphogen gradient. |
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