Effective prophylaxis against rotavirus diarrhea using a combination of Lactobacillus rhamnosus GG and antibodies |
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| Authors: | Neha Pant Harold Marcotte Harald Brüssow Lennart Svensson Lennart Hammarström |
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| Affiliation: | 1.Division of Clinical Immunology, Department of Laboratory Medicine,Karolinska Institutet at Karolinska University Hospital Huddinge,Stockholm,Sweden;2.Nutrition and Health Department, Food and Health Microbiology,Nestlé Research Centre,Lausanne,Switzerland;3.Division of Molecular Virology,University of Link?ping,Link?ping,Sweden |
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| Abstract: | Background Rotavirus is a worldwide cause of infectious infantile diarrhea that claims over 600,000 lives annually. Recently, two new vaccine candidates have been developed but their efficacy in developing countries, still remains to be proven. Oral delivery of specific immunoglobulins provides passive immunity and is a fast acting treatment for rotavirus diarrhea. Probiotic bacteria have also gained considerable attention lately as treatment for rotavirus diarrhea. Here we report an evaluation of the therapeutic potential of different probiotics and their combination with anti - rotavirus antibodies in a mouse model of rotavirus diarrhea. |
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