Laboratory methods to improve SELDI peak detection and quantitation |
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| Authors: | Dominique Rollin Toni Whistler Suzanne D Vernon |
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| Affiliation: | (1) Chronic Viral Diseases Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS-G41 Atlanta, Georgia, 30333, USA |
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| Abstract: | Background Protein profiling with surface-enhanced laser desorption-ionisation time-of-flight mass spectrometry (SELDI-TOF MS) is a promising approach for biomarker discovery. Some candidate biomarkers have been identified using SELDI-TOF, but validation of these can be challenging because of technical parameters that effect reproducibility. Here we describe steps to improve the reproducibility of peak detection. |
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