An immunohistochemical study of the localization and developmental expression of ghrelin and its functional receptor in the ovine placenta |
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| Authors: | Joanne L Harrison Clare L Adam Yvonne A Brown Jacqueline M Wallace Raymond P Aitken Richard G Lea David W Miller |
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| Institution: | (1) School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA, Australia;(2) Obesity & Metabolic Health Division, Rowett Research Institute, Bucksburn, Aberdeen, UK;(3) School of Biological Sciences, University of Aberdeen, Aberdeen, UK;(4) Sustainable Livestock Systems Group, Scottish Agricultural College, Bucksburn, Aberdeen, UK;(5) School of Veterinary Medicine and Science, University of Nottingham,Sutton Bonington Campus, Leicestershire, UK |
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| Abstract: | Background Ghrelin is an orexigenic hormone principally produced by the stomach, but also by numerous peripheral tissues including the
placenta. Ghrelin acts via growth hormone secretagogue receptors (GHSR-1a) to alter food intake, fat utilization, and cellular
proliferation, and has been suggested to play a role in the developmental growth of the fetoplacental unit. The placental
expression of ghrelin and its role in ruminant species is not known. We tested the hypotheses that ghrelin and its functional
receptor, GHSR-1a, are present in tissues of the ovine placenta, and that their expression is linked to the stage of development. |
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