Maternal and neonatal disposition of pethidine in childbirth--a study using quantitative gas chromatography-mass spectrometry |
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| Authors: | J Caldwell L A Wakile L J Notarianni R L Smith G J Correy B A Lieberman R W Beard M D Finnie W Snedden |
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| Institution: | 1. Department of Biochemical and Experimental Pharmacology, St Mary''s Hospital Medical School, London W2 1PG, U.K.;7. Departments of Obstetrics and Gynaecology, St Mary''s Hospital Medical School, London W2 1PG, U.K. |
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| Abstract: | An assay for pethidine using gas chromatography-mass spectrometry with single ion monitoring has been developed for its analysis in the blood of neonates whose mothers received pethidine during childbirth. Concentrations were determined from the height of the peak at m/e 218 derived from pethidine compared with that at m/e 234 derived from the internal standard lignocaine. Results from 10 mothers and their babies show the time-related passage of pethidine across the placenta. The elimination half-life of the drug from neonatal blood was 22.7h compared with 3h in the adult. |
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| Keywords: | Pethidine Quantitative Gas Chromatography — Mass Spectrometry Obstetric analgesic Placental transfer Neonatal drug disposition |
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