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慢性呼吸衰竭病人红细胞膜蛋白和红细胞变形能力的研究
引用本文:杨晓静,钱桂生.慢性呼吸衰竭病人红细胞膜蛋白和红细胞变形能力的研究[J].中国应用生理学杂志,1999,15(2):173-175.
作者姓名:杨晓静  钱桂生
作者单位:第三军医大学新桥医院呼吸内科研究所
摘    要:目的:探讨红细胞膜蛋白在红细胞变形性改变中的作用。方法:参照Leammli和Peacock方法,测定了肺心病Ⅰ型呼吸衰竭(Ⅰ组)18例、Ⅱ型呼吸衰竭(Ⅱ组)18例和健康对照(CG)20例的红细胞膜带3蛋白、膜收缩蛋白二聚体(SpD)和四聚体(SpT)的相对含量与红细胞变形能力。结果:Ⅰ、Ⅱ组带3蛋白、SpD、SpT相对含量和红细胞变形指数(DI)与对照组均有显著差异,且肺心病病人的DI与带3蛋白相对含量呈显著正相关,与SpD/SpT比值呈显著负相关。结论:带3蛋白和膜收缩蛋白的异常,可能是导致肺心病人红细胞变形能力降低的重要因素之一。

关 键 词:红细胞  带3蛋白  膜收缩蛋白  呼吸衰竭

STUDY OF ERYTHROCYTE MEMBRANE PROTEINS AND DEFORMABILITY IN PATIENTS WITH RESPIRATORY FAILURE
Yang Xiaojing,Qian Guisheng,Mao Baoling.STUDY OF ERYTHROCYTE MEMBRANE PROTEINS AND DEFORMABILITY IN PATIENTS WITH RESPIRATORY FAILURE[J].Chinese Journal of Applied Physiology,1999,15(2):173-175.
Authors:Yang Xiaojing  Qian Guisheng  Mao Baoling
Abstract:Aim and Methods:To investigate the role of erythrocyte membrane protein in the changes of erythrocyte deformability. The changes of erythrocyte deformability and band 3 protein and spectrin dimers(Sp D) and tetramers (Sp T) were studied in 18 cases of respiratory fairlure type I (group I) and 18 cases of respiratory failure type II (group II) and 15 normal subjects,using the methods of Chang,Liammli and peacock. Results: The erythrocyte deformation index and relative content of band 3 protein and Sp T were significantly lower in group I and II than that in CG . The relative content of Sp D and ratio of Sp D/Sp T were signficanitly higher in group I and II than in CG. The erythrocyte deformability in group I and II were positively related to the ratio of Sp D/Sp T. Conclusion: These findings suggested that the abnormality of band 3 and spectrin may be one of the reasons that resulted in erythrocyte deformability decrease in cor pulmonale patients with respiratory failure.
Keywords:erythrocyte membrane  bands 3 protein  Spectrin  Respiratory failure  
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