A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library

We have successfully developed a new strategy for RNA ligand design, which applies the antisense concept to enhance and make more specific loop region interactions while at the same time preserving stem region anchoring. The heteroconjugates, prepared in this effort, have proven to be the most specific small molecule ligands against RRE RNA that have been uncovered to date.