Circular dichroism spectra and ethidium bromide binding of 5-deoxybromouridine-substituted chromatin. |
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| Authors: | C Nicolini R Baserga |
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| Affiliation: | 1. Department of Physiology and Biophysics Temple University Health Sciences Center Philadelphia, Pennsylvania 19140, USA;7. Department of Pathology and Fels Research Institute Temple University Health Sciences Center Philadelphia, Pennsylvania 19140, USA |
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| Abstract: | Changes in CD spectra of 5-deoxybromouridine (brUdRib)-substituted chromatin depend on the extent of thymidine replacement by brUdRib. With 20 and 14 per cent replacement, a blue shift and a marked increase in positive ellipticity are reported in the CD spectra of brUdRib-substituted chromatin, while with 4.9 per cent replacement little effect is noticed. BrUdRib-substitution does not affect the number of ethidium bromide primary binding sites of chromatin. |
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