Study of <Emphasis Type="Italic">In Vitro</Emphasis> Drug Release and Percutaneous Absorption of Fluconazole from Topical Dosage Forms |
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Authors: | Claudia Salerno Adriana M Carlucci Carlos Bregni |
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Institution: | (1) Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junin 954, 1113 Buenos Aires, Argentina |
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Abstract: | The present study aimed to evaluate different dosage forms, emulsions, emulgels, lipogels, and thickened microemulsion-based
hydrogel, as fluconazole topical delivery systems with the purpose of determining a formulation with the capacity to deliver
the whole active compound and maintain it within the skin so as to be considered a useful formulation either for topical mycosis
treatment or as adjuvant in a combined therapy for Cutaneous Leishmaniasis. Propylene glycol and diethyleneglycol monoethyl
ether were used for each dosage form as solvent for the drug and also as penetration enhancers. In vitro drug release after application of a clinically relevant dose of each formulation was evaluated and then microemulsions and
lipogels were selected for the in vitro penetration and permeation study. Membranes of mixed cellulose esters and full-thickness pig ear skin were used for the in vitro studies. Candida albicans was used to test antifungal activity. A microemulsion containing diethyleneglycol monoethyl ether was found to be the optimum
formulation as it was able to deliver the whole contained dose and enhance its skin penetration. Also this microemulsion showed
the best performance in the antifungal activity test compared with the one containing propylene glycol. These results are
according to previous reports of the advantages of microemulsions for topical administration and they are very promising for
further clinical evaluation. |
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