Development of cortical circuits: lessons from ocular dominance columns |
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Authors: | Katz Lawrence C Crowley Justin C |
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Affiliation: | Howard Hughes Medical Institute and Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA. larry@neuro.duke.edu |
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Abstract: | The development of ocular dominance columns has served as a Rosetta stone for understanding the mechanisms that guide the construction of cortical circuits. Traditionally, the emergence of ocular dominance columns was thought to be closely tied to the critical period, during which columnar architecture is highly susceptible to alterations in visual input. However, recent findings in cats, monkeys and ferrets indicate that columns develop far earlier, more rapidly and with considerably greater precision than was previously suspected. These observations indicate that the initial establishment of cortical functional architecture, and its subsequent plasticity during the critical period, are distinct developmental phases that might reflect distinct mechanisms. |
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