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Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility
Authors:Shan Herath  Sonia T Lilly  Natalia R Santos  Robert O Gilbert  Leopold Goetze  Clare E Bryant  John O White  James Cronin  IMartin Sheldon
Affiliation:(1) Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Royal College Street, London, NW1 0TU, UK;(2) Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA;(3) Pfizer Animal Health Europe, 23–25, avenue du Dr Lannelongue, F-75668 Paris Cedex 14, France;(4) Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK;(5) Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea, SA2 8PP, UK
Abstract:

Background  

Contamination of the uterine lumen with bacteria is ubiquitous in cattle after parturition. Some animals develop endometritis and have reduced fertility but others have no uterine disease and readily conceive. The present study tested the hypothesis that postpartum cattle that develop persistent endometritis and infertility are unable to limit the inflammatory response to uterine bacterial infection.
Keywords:
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