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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates |
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| Authors: | Xiaoying Shen Ryan Duffy Robert Howington Alethea Cope Shanmugalakshmi Sadagopal Haesun Park Ranajit Pal Suefen Kwa Song Ding Otto O Yang Genevieve G Fouda Roger Le Grand Diane Bolton Mariano Esteban Sanjay Phogat Mario Roederer Rama R Amara Louis J Picker Robert A Seder M Juliana McElrath Susan Barnett Sallie R Permar Robin Shattock Anthony L DeVico Barbara K Felber George N Pavlakis Giuseppe Pantaleo Bette T Korber David C Montefiori Georgia D Tomaras |
| Abstract: | To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen. |
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