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A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis
Authors:Chunbo He  Xiangmin Lv  Cong Huang  Peter C Angeletti  Guohua Hua  Jixin Dong  Jin Zhou  Zhengfeng Wang  Bowen Ma  Xingcheng Chen  Paul F Lambert  Bo R Rueda  John S Davis  Cheng Wang
Institution:1. Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA;2. Olson Center for Women’s Health, Department of Obstetrics & Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, USA;3. College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China;4. Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA;5. Fred & Pamela Cancer Center, University of Nebraska Medical Center, Omaha NE 68198, USA;6. Department of Obstetrics and Gynecology, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518033, China;7. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45001 China;8. McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705, USA;9. Omaha Veterans Affairs Medical Center, Omaha, NE 68105, USA
Abstract:
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  • Keywords:Hippo pathway  YAP1 oncogene  HPV infection  cervical carcinogenesis  cervical cancer mouse model  innate immunity  molecular mechanism  HPV receptor molecules  type I interferon  interferon-stimulated genes
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