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The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus |
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| Authors: | Matteo Gentili Xavier Lahaye Francesca Nadalin Guilherme FP Nader Emilia Puig Lombardi Solène Herve Nilushi S De Silva Derek C Rookhuizen Elina Zueva Christel Goudot Mathieu Maurin Aurore Bochnakian Sebastian Amigorena Matthieu Piel Daniele Fachinetti Arturo Londoño-Vallejo Nicolas Manel |
| Institution: | 1. Immunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France;2. Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France;3. Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France;4. Institut Curie, PSL Research University, Sorbonne Universités, CNRS, UMR 3244 Telomere and Cancer Lab, 75005 Paris, France |
| Abstract: |  |
| Keywords: | cGAS cGAMP STING IRF3 centromere LINE satellite DNA dendritic cells interferon nuclear envelope |
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