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Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development
Authors:Shangli Cheng  Yu Pei  Liqun He  Guangdun Peng  Björn Reinius  Patrick PL Tam  Naihe Jing  Qiaolin Deng
Institution:1. Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Solna, Sweden;2. Center for Molecular Medicine, Karolinska University Hospital, 17176 Solna, Sweden;3. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, 300052 Tianjin, China;4. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China;5. CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530 Guangzhou, China;6. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Solna, Sweden;7. Embryology Unit, Children’s Medical Research Institute, The University of Sydney and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145, Australia;8. School of Life Science and Technology, Shanghai Tech University, 201210 Shanghai, China;9. School of Life Sciences and Technology, Tongji University, 200092 Shanghai, China
Abstract:
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  • Keywords:pluripotency transition  epiblast heterogeneity  pregastrula development  X chromosome inactivation dynamics
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