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SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
Authors:Anna R. Malik  Kinga Szydlowska  Karolina Nizinska  Antonino Asaro  Erwin A. van Vliet  Oliver Popp  Gunnar Dittmar  Raphaela Fritsche-Guenther  Jennifer A. Kirwan  Anders Nykjaer  Katarzyna Lukasiuk  Eleonora Aronica  Thomas E. Willnow
Affiliation:1. Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany;2. Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland;3. Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, the Netherlands;4. Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH, Amsterdam, the Netherlands;5. Department of Oncology, Luxembourg Institute of Health, 1445 Strassen, Luxembourg;6. Berlin Institute of Health Metabolomics Platform, 10178 Berlin, Germany;7. MIND Center, Danish Research Institute of Translational Neuroscience - DANDRITE, The Danish Research Foundation Center PROMEMO, Departments of Biomedicine, Aarhus University, and Neurosurgery, Aarhus University Hospital, 8000C Aarhus, Denmark;8. Stichting Epilepsie Instellingen Nederland (SEIN), 2103 SW Heemstede, the Netherlands
Abstract:
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  • Keywords:VPS10P domain receptors  intracellular protein sorting  oxidative stress  EAAT3  EAAC1  epilepsy  glutathione
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