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Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor
Authors:Yukinori Terada  Norihide Jo  Yoshiki Arakawa  Megumi Sakakura  Yosuke Yamada  Tomoyo Ukai  Mio Kabata  Kanae Mitsunaga  Yohei Mineharu  Sho Ohta  Masato Nakagawa  Susumu Miyamoto  Takuya Yamamoto  Yasuhiro Yamada
Institution:1. Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;2. Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;3. Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;4. AMED-CREST, AMED 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan;5. Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Abstract:
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  • Keywords:atypical teratoid/rhabdoid tumor  pediatric tumor  embryonic stem cell  induced pluripotent stem cell  ESC-like signature  pluripotency  dedifferentiation  Corresponding author
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