Selection of Penicillium funiculosum Strains with High Glucose Oxidase Activity

Metabolic inhibitors, riboflavin, and end products of glucose oxidation were shown to be effective for the selection ofPenicillium funiculosum mutant strains with a high glucose oxidase activity. The incidence of positive mutations was highest in clones resistant to sodium azide, riboflavin, and -D-glucono--lactone. Enzyme activity in Penicillium funiculosum mutants was studied in submerged culture. The level of glucose oxidase synthesis in seven cultures was 24–56% higher than that in the parent strain of Penicillium funiculosum NMM95.132.