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Nucleic acid components and their analogs: Design and synthesis of novel cytosine thioglycoside analogs |
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| Authors: | Galal H. Elgemeie Ali M. Salah Nermeen S. Abbas Hoda A. Hussein Reham A. Mohamed |
| Affiliation: | 1. Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt;2. Chemistry Department, Faculty of Science, Taibah University, Saudi Arabia;3. Photochemistry Department, National Research Center, Dokki, Cairo, Egypt |
| Abstract: | The synthesis of a new category of novel cytosine 4-thioglycoside analogs has been first accomplished. The main step of this strategy is the synthesis of sodium pyrimidine-4-thiolate through the condensation of 2-cyano-N-arylacetamides with sodium cyanocarbonimidodithioate, followed by coupling with α-bromo-sugars to afford the corresponding cytosine 4-thioglycoside analogs. The free thioglycosides were also prepared. Subsequent studies on the application of this strategy for the preparation of other potent pyrimidine thioglycosides are reported. |
| Keywords: | Pyrimidine thioglycosides antimetabolites 2-cyano-N-arylacetamides sodium cyanocarbonimidodithioate |