Pyrimidine non-nucleoside analogs: A direct synthesis of a novel class of N-substituted amino and N-sulfonamide derivatives of pyrimidines |
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| Authors: | Galal H. Elgemeie Ali M. Salah Nermeen S. Abbas Hoda A. Hussein Reham A. Mohamed |
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| Affiliation: | 1. Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt;2. Chemistry Department, Faculty of Science, Taibah University, Saudi Arabia;3. Photochemistry Department, National Research Center, Dokki, Cairo, Egypt |
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| Abstract: | A convenient method for the regioselective synthesis of pyrimidine non-nucleoside analogs was developed. This study reports a novel and efficient method for the synthesis of a new type of N-substituted amino methylsulfanylpyrimidines and the corresponding pyrazolo[3,4-d]pyrimidines. This series of compounds was designed through the reaction of dimethyl N-cyanodithioiminocarbonate with 2-cyano-N′-(thiophen-2-yl-, furan-2-yl- and pyridin-4-ylmethylene)acetohydrazide and N′-(2-cyanoacetyl)arylsulfonohydrazides. The scope and limitation of the method are demonstrated. The antibacterial and antifungal activities of the synthesized compounds were also evaluated. |
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| Keywords: | N-substituted amino methylsulfanylpyrimidines dimethyl N-cyanodithioiminocarbonate N′-(2-cyanoacetyl)arylsul-fonohydrazides antibacterial and antifungal activities 2-cyano-N′-(thiophen-2-yl-, furan-2-yl- and pyridin-4-ylmethylene)acetohydrazide pyrazolo[3,4-d]pyrimidines, purine analogs |
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