Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus |
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| Authors: | Qu Shi-Jin Wang Gui-Feng Duan Wen-Hu Yao Shan-Yan Zuo Jian-Ping Tan Chang-Heng Zhu Da-Yuan |
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| Institution: | Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. |
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| Abstract: | A series of tryptamine derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent antiviral activity (IC(50)=0.4 and <1 μM, respectively) and low cytotoxicity (CC(50)=40.6 and >25 μM, respectively). |
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