Microbial transformation of hydrocortisone by Acremonium strictum PTCC 5282 |
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Authors: | Faramarzi Mohammad Ali Yazdi Mojtaba Tabatabaei Shafiee Abbas Zarrini Gholamreza |
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Institution: | Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, 14174, Tehran, Iran. |
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Abstract: | The ability of a genus of cephalosporium-like fungus isolated from soil, Acremonium strictum PTCC 5282, for hydrocortisone biotransformation has been investigated. This potential had not been previously examined. The fermentation yielded 11beta,17beta-dihydroxyandrost-4-en-3-one, 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one and 21-acetoxy-11beta,17alpha,20-trihydroxypregn-4-en-3-one. Each microbial metabolite was purified and characterized using spectroscopic methods. |
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