ClpC-Mediated Sporulation Regulation at Engulfment Stage in Bacillus anthracis |
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Authors: | Nishant Kumar Aakriti Gangwal Nitika Sangwan Neha Dhasmana Chetkar Chandra Keshavam Ekta Tyagi Yogendra Singh |
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Affiliation: | 1.CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007 India ;2.Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India ;3.Department of Zoology, University of Delhi, Delhi, 110007 India |
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Abstract: | Bacterial sporulation is a conserved process utilized by members of Bacillus genus and Clostridium in response to stress such as nutrient or temperature. Sporulation initiation is triggered by stress signals perceived by bacterial cell that leads to shutdown of metabolic pathways of bacterial cells. The mechanism of sporulation involves a complex network that is regulated at various checkpoints to form the viable bacterial spore. Engulfment is one such check point that drives the required cellular rearrangement necessary for the spore assembly and is mediated by bacterial proteolytic machinery that involves association of various Clp ATPases and ClpP protease. The present study highlights the importance of degradation of an anti-sigma factor F, SpoIIAB by ClpCP proteolytic machinery playing a crucial role in culmination of engulfment process during the sporulation in Bacillus anthracis. |
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Keywords: | Sporulation Engulfment ClpC Bacillus anthracis Proteolysis |
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