Sesquiterpenes from the red alga Laurencia tristicha |
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Institution: | 1. Division of Clinical Pharmacology II, Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland;2. College of Pharmacy, Oregon State University, Corvallis, Oregon;3. Division of Pulmonary, Allergy, and Rheumatology Products, Office of Drug Evaluation II, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland |
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Abstract: | Phytochemical investigation on Laurencia tristicha afforded eleven cuparane-derived sesquiterpenes, including ten monomers and one dimer, and their structures were elucidated by a combination of spectroscopic analysis and comparison with those reported in literature. Four compounds, laurinterol acetate, debromolaurinterol acetate, aplysinal, and (−)-α-bromocuparene were obtained from L. tristicha for the first time. Additionally, the chemotaxonomic significance of these cuparane-derived sesquiterpenes, as well as their plausible biogenetic pathway, was also discussed. |
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Keywords: | Red alga Sesquiterpene Chemotaxonomic significance |
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