A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice |
| |
Authors: | Jeremy L Peirce Rachel Derr Jay Shendure Therese Kolata Lee M Silver |
| |
Institution: | (1) Princeton University, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA, US |
| |
Abstract: | C57Bl/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this
paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr 11. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4, a female-specific locus on Chr 1. We have also performed a statistical analysis to exclude the possibility of undiscovered
major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference
in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner.
Received: 15 September 1998 / Accepted: 8 October 1998 |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|