Interaction of vasoactive intestinal peptide with rat small intestinal epithelial cells after intestinal resection |
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| Authors: | José L Diaz-Juarez Guillermo Bodega Eduardo Arilla Juan C Prieto |
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| Institution: | (1) Departamento de Bioquímica, Facultad de Medicina, Universidad de Alacalá de Henares, Madrid, Spain;(2) Departamento de Histología, Facultad de Ciencias, Universidad de Alacalá de Henares, Madrid, Spain |
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| Abstract: | Specific binding of vasoactive intestinal peptide (VIP) and VIP-stimulated c y c l i c AMP accumulation were studied in small intestinal epithelial cells (both of crypt and villous levels) 3, 7 and 14 d after a 60% resection of the small intestine . The affinity, but not the binding capacity, of VIP receptors decreased during the adaptive hyperplastic response. Basal cyclic AMP levels were similar in cells of both control and resected rats. Resection induced a decrease of potency, but not of efficiency, of VIP on the stimulation of cyclic AMP accumulation. |
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