Genomic Structure and Chromosomal Mapping of the MousenovGene |
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| Authors: | Michael R Snaith Dipa Natarajan Lucy B Taylor Chi-Pa Choi Cecile Martinerie Bernard Perbal Paul N Schofield Catherine A Boulter |
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| Institution: | aDepartment of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, United Kingdom;dDepartment of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3EH, United Kingdom;bLaboratoire d'Oncologie Virale et Moleculaire, Institut Curie, 91405, Orsay Cedex, France;cUFR de Biochemie, Universite Paris 7-D, Diderot, France |
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| Abstract: | Thenovgene encodes a cysteine-rich protein that is overexpressed in avian nephroblastomas. It is a member of the CCN family of proteins, all of which are involved in cell growth. Genomic and cDNA clones encompassing the mousenovgene have been isolated and characterized. The mousenovgene is highly conserved with the human and chicknovgenes at the level of nucleotide sequence and genomic organization. The exon structure reflects the modular organization of the NOV protein in a number of structural domains. These are highly conserved with other members of the CCN family, as is the distribution of 38 of its 40 cysteine residues. Thenovgene maps to chromosome 15, between D15 Mit 153 and D15 Mit 183, in a region of conserved synteny with human chromosome 8. |
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